Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Shionoiri H, Gotoh E, Ito T, Hata T, Iwatsubo H, Takegawa K, Ogihara T, Mikami H, Ikegami H, Otsuka A, Katahira K, Kawaguchi Y "Long-term therapy with terazosin may improve glucose and lipid metabolism in hypertensives - a multicenter prospective study.
Metabolic side effects have included decreases in serum triglycerides and VLDL cholesterol, and increases in HDL cholesterol. Terazosin the active ingredient contained in Hytrin may counterbalance deleterious effects on the lipid profile associated with thiazide diuretics, making it a reasonable drug to use in combination with these agents. Hytrin may cause drowsiness, dizziness, blurred vision, or lightheadedness. These effects may be worse if you take it with alcohol or certain medicines. Use Hytrin with caution. Check with your pharmacist about how to dispose of unused medicine. Testicular weights and morphology were unaffected by treatment.
Keep Hytrin and all medicines out of the reach of children. Please read this leaflet before you start taking Hytrin. Also, read it each time you get a new prescription. This is a summary and should NOT take the place of a full discussion with your doctor who has additional information about Hytrin. You and your doctor should discuss Hytrin and your condition before you start taking it and at your regular check-ups. The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine.
Keep out of the reach of children. In a short term study Study 1 patients were randomized to either 2, 5 or 10 mg of Hytrin or placebo. You will start with a 1 mg dose of Hytrin. Then the dose will be increased as your body gets used to the effect of the medication. This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. AUC 0-24 increased 11% after the first verapamil dose and after 3 weeks of verapamil treatment it increased by 24% with associated increases in C max 25% and C min 32% means.
Hytrin works by relaxing blood vessels so that blood passes through them more easily. This helps to lower blood pressure. What is BPH? Use and dose must be determined by your doctor. Statistically significant differences were not found in the verapamil level with and without terazosin. Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. HernandezCano N, Herranz P, Lazaro TE, Mayor M, Casado M "Severe cutaneous reaction due to terazosin. Store Hytrin at room temperature, between 68 and 77 degrees F 20 and 25 degrees C. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Hytrin out of the reach of children and away from pets. Terazosin has been extensively studied in 1222 men with symptomatic BPH. In three placebo-controlled studies, symptom evaluation and uroflowmetric measurements were performed approximately 24 hours following dosing. Symptoms were systematically quantified using the Boyarsky Index. The questionnaire evaluated both obstructive hesitancy, intermittency, terminal dribbling, impairment of size and force of stream, sensation of incomplete bladder emptying and irritative nocturia, daytime frequency, urgency, dysuria symptoms by rating each of the 9 symptoms from 0-3, for a total score of 27 points. It may take up to 6 weeks before your symptoms get better. Bottles of 100 NDC 0074-3324-13. Lab tests, including blood pressure, may be performed while you use Hytrin. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments. Hytrin may rarely cause a prolonged, painful erection. This could happen even when you are not having sex. If this is not treated right away, it could lead to permanent sexual problems such as impotence. Contact your doctor right away if this happens. Carcinoma of the prostate and BPH cause many of the same symptoms. These two diseases frequently co-exist. Therefore, patients thought to have BPH should be examined prior to starting Hytrin therapy to rule out the presence of carcinoma of the prostate. The use of the Truven Health products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Truven Health and Drugs.
Use Hytrin as directed by your doctor. Check the label on the medicine for exact dosing instructions. Lowe FC "Safety assessment of terazosin in the treatment of patients with symptomatic benign prostatic hyperplasia - a combined analysis. Hytrin helps relieve the symptoms of BPH. It does NOT change the size of the prostate, which may continue to grow. However, a larger prostate does not necessarily cause more or worse symptoms. Patients should be closely followed during initial administration in order to minimize the risk of severe hypotensive response. Terazosin helps to lower blood pressure by relaxing blood vessels so that blood passes through them more easily. zyloprim
The responses in the standing position tended to be somewhat larger, by 1-3 mmHg, although this was not true in all studies. The magnitude of the blood pressure responses was similar to prazosin and less than hydrochlorothiazide in a single study of hypertensive patients. In measurements 24 hours after dosing, heart rate was unchanged. Extremely rarely, Hytrin and similar medications have caused painful erection of the penis, sustained for hours and unrelieved by sexual intercourse or masturbation. This condition is serious, and if untreated it can be followed by permanent inability to have an erection. If you have a prolonged abnormal erection, call your doctor or go to an emergency room as soon as possible. If high blood pressure is not treated, over time, the increased pressure can damage blood vessels or it can cause the heart to work too hard and may decrease the flow of blood to the heart, brain, and kidneys. As a result, these organs may become damaged and not function correctly. If high blood pressure is controlled, this damage is less likely to happen. In animals, terazosin causes a decrease in blood pressure by decreasing total peripheral vascular resistance. The vasodilatory hypotensive action of terazosin appears to be produced mainly by blockade of alpha-1 adrenoceptors. Terazosin decreases blood pressure gradually within 15 minutes following oral administration. Doses of 10 mg once daily are generally required for the clinical response. Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Lepor H. Role of alpha-adrenergic blockers in the treatment of benign prostatic hypertrophy. krom.info danocrine
Koh MJ, Seah PP, Tay YK, Mancer K "Lichenoid drug eruption to terazosin. If syncope occurs, the patient should be placed in a recumbent position and treated supportively as necessary. There is evidence that the orthostatic effect of Hytrin tablets is greater, even in chronic use, shortly after dosing. The risk of the events is greatest during the initial seven days of treatment, but continues at all time intervals. In this long-term trial, both symptom scores and peak urinary flow rates showed statistically significant improvement suggesting a relaxation of smooth muscle cells. Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. Female rats were unaffected. In multiple dose clinical trials involving nearly 2000 hypertensive patients treated with Hytrin tablets, syncope was reported in about 1% of patients. Syncope was not necessarily associated only with the first dose. Do not consider WebMD User-generated content as medical advice. Never delay or disregard seeking professional medical advice from your doctor or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences can be a helpful resource but it is never a substitute for professional medical advice, diagnosis, or treatment from a qualified health care provider. If you think you may have a medical emergency, call your doctor or dial 911 immediately. Nasal congestion and symptoms of sinusitis or dyspnea may be due to alpha-adrenergic blockade. Patients who take medicine for high blood pressure often feel tired or run down for a few weeks after starting treatment. Be sure to take your medicine even if you may not feel "normal. tecta online visa mail order
Respiratory system side effects have been limited to nasal congestion in 2% to 12% of patients. Hytrin Can Cause A Sudden Drop in Blood Pressure After the VERY FIRST DOSE. You may feel dizzy, faint, or "light-headed" particularly after you get up from bed or from a chair. This is more likely to occur after you've taken the first few doses, but can occur at any time while you are taking the drug. It can also occur if you stop taking the drug and then re-start treatment. Dizziness, lightheadedness, or fainting especially when getting up from a lying or sitting position may be more likely to occur in the elderly, who are more sensitive to the effects of terazosin. Global assessments of overall urinary function and symptoms were also performed by investigators who were blinded to patient treatment assignment. The rash was accompanied by mild fever, asthenia, and intense pruritus. The patient was on no other medications. Hematologic and histopathologic studies suggested a drug reaction. Terazosin was discontinued. Two weeks following oral methylprednisolone 40 mg daily and emollients, symptoms had resolved completely. Limited measurements of peak response 2-3 hours after dosing during chronic terazosin administration indicate that it is greater than about twice the trough 24 hour response, suggesting some attenuation of response at 24 hours, presumably due to a fall in blood terazosin concentrations at the end of the dose interval. To help you remember to take your medicine, try to get into the habit of taking it at the same time each day. Hytrin may cause a sudden drop in blood pressure after the first dose. Take your first dose at bedtime. If you get up during the night, sit up slowly, then stand slowly. This will help to reduce your lightheadedness or dizziness. These effects are more likely to occur after the first few doses or if your dose has increased, but can occur at any time while you are taking the medicine. It can also occur if you stop taking the medicine and then restart treatment. Terazosin may cause some people to become drowsy or less alert than they are normally. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy, drowsy, or are not alert. After you have taken several doses of this medicine, these effects should lessen. The dose may be slowly increased to achieve the desired blood pressure response. The usual recommended dose range is 1 mg to 5 mg administered once a day; however, some patients may benefit from doses as high as 20 mg per day. Doses over 20 mg do not appear to provide further blood pressure effect and doses over 40 mg have not been studied. Blood pressure should be monitored at the end of the dosing interval to be sure control is maintained throughout the interval. It may also be helpful to measure blood pressure 2-3 hours after dosing to see if the maximum and minimum responses are similar, and to evaluate symptoms such as dizziness or palpitations which can result from excessive hypotensive response. If response is substantially diminished at 24 hours an increased dose or use of a twice daily regimen can be considered. If terazosin administration is discontinued for several days or longer, therapy should be reinstituted using the initial dosing regimen. In clinical trials, except for the initial dose, the dose was given in the morning. Hytrin was devoid of mutagenic potential when evaluated in vivo and in vitro the Ames test, in vivo cytogenetics, the dominant lethal test in mice, in vivo Chinese hamster chromosome aberration test and V79 forward mutation assay. Caution should be observed when Hytrin tablets are administered concomitantly with other antihypertensive agents, especially the calcium channel blocker verapamil, to avoid the possibility of developing significant hypotension. When using Hytrin tablets and other antihypertensive agents concomitantly, dosage reduction and retitration of either agent may be necessary see PRECAUTIONS. Hypotension has been reported when Hytrin has been used with phosphodiesterase-5 PDE-5 inhibitors.
In controlled trials, Hytrin tablets have been added to diuretics, and several beta-adrenergic blockers; no unexpected interactions were observed. Hytrin tablets have also been used in patients on a variety of concomitant therapies; while these were not formal interaction studies, no interactions were observed. At first, 1 mg taken at bedtime. Then, 1 to 5 mg once a day. Nervous system side effects, such as dizziness 5% to 30% of patients and blurred vision 2% of patients may be related to hypotension. Headaches 2% to 10% asthenia 8% and somnolence 6% have occurred following long-term use. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs including any herbal medicines or supplements or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you. At first, 1 milligram mg taken at bedtime. Then, 5 to 10 mg once a day. Rarely, probably less than once in every several thousand patients terazosin and other α 1-antagonists have been associated with priapism painful penile erection, sustained for hours and unrelieved by sexual intercourse or masturbation. Two or three dozen cases have been reported. Because this condition can lead to permanent impotence if not promptly treated, patients must be advised about the seriousness of the condition see PRECAUTIONS - Information for Patients. If Hytrin administration is discontinued for several days, therapy should be reinstituted using the initial dosing regimen. Hernandez RH, Angeligreaves M, Carvajal AR, Pajuelo JG, Padilla MCA, Armashernandez MJ "Terazosin: ex vivo and in vitro platelet aggregation effects in patients with arterial hypertension. Because terazosin, like all alpha antagonists, can cause unusually large falls in blood pressure after the first dose or first few doses, the initial dose was 1 mg in virtually all trials, with subsequent titration to a specified fixed dose or titration to some specified blood pressure end point usually a supine diastolic pressure of 90 mmHg. Oddly enough, though, I think this has led to another problem. I've developed nocturia and often have to get up from bed to urinate. Now that my flow is strengthened due to this med, I often have incontinence if I'm in a deep sleep and the urge doesn't wake me up in time. Not sure of this, of course, but it seems logical. The dizziness, lightheadedness, or fainting is more likely to occur if you drink alcohol, stand for long periods of time, exercise, or if the weather is hot. While you are taking this medicine, be careful to limit the amount of alcohol you drink. Also, use extra care during exercise or hot weather or if you must stand for long periods of time. Cardiovascular side effects have included orthostatic hypotension, which generally occurs within 30 to 60 minutes after the first dose. For this reason, it is recommended that the first dose be administered at bedtime. Other symptoms of hypotension, such as mild to moderate dizziness, lightheadedness, palpitations and weakness have occurred in 1% to 30% of patients. Some cardiovascular side effects, particularly dizziness, have been more prevalent among persons greater than 65 years old. During controlled clinical trials, patients receiving terazosin monotherapy had a small but statistically significant decrease a 3% fall compared to placebo in total cholesterol and the combined low-density and very-low-density lipoprotein fractions. No significant changes were observed in high-density lipoprotein fraction and triglycerides compared to placebo. Terazosin hydrochloride is a white, crystalline substance, freely soluble in water and isotonic saline and has a molecular weight of 459. Bottles of 100 NDC 0074-3323-13. Dizziness; drowsiness; lightheadedness; nasal congestion; nausea; weakness. price condylox vidal
Do not keep outdated medicine or medicine no longer needed. Further dose response and dose duration studies are being carried out. Blood pressure should be measured at the end of the dose interval; if response is not satisfactory, patients may be tried on a larger dose or twice daily dosing regimen. The latter should also be considered if possibly blood pressure-related side effects, such as dizziness, palpitations, or orthostatic complaints, are seen within a few hours after dosing. Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables. Additional adverse reactions have been reported, but these are, in general, not distinguishable from symptoms that might have occurred in the absence of exposure to terazosin. Increased fetal resorptions, decreased fetal weight and an increased number of supernumerary ribs were observed in offspring of rabbits dosed with 60 times the maximum recommended human dose. These findings in both species were most likely secondary to maternal toxicity. There are no adequate and well-controlled studies in pregnant women and the safety of terazosin in pregnancy has not been established. Hytrin is not recommended during pregnancy unless the potential benefit justifies the potential risk to the mother and fetus. The presence of other medical problems may affect the use of this medicine. Mersey JH "Long-term experience with terazosin for treatment of mild to moderate hypertension. Even though you take Hytrin and it may help you, Hytrin may not prevent the need for surgery in the future. Product Information. Hytrin terazosin. Achari R, Laddu A "Terazosin: a new alpha adrenoceptor blocking drug. Other side effects you could have while taking Hytrin include drowsiness, blurred or hazy vision, nausea, or "puffiness" of the feet or hands. Discuss any unexpected effects you notice with your doctor. Highest dose 10 mg shown. The drug is highly bound to plasma proteins and binding is constant over the clinically observed concentration range. Approximately 10% of an orally administered dose is excreted as parent drug in the urine and approximately 20% is excreted in the feces. The remainder is eliminated as metabolites. Impaired renal function had no significant effect on the elimination of terazosin, and dosage adjustment of terazosin to compensate for the drug removal during hemodialysis approximately 10% does not appear to be necessary. Overall, approximately 40% of the administered dose is excreted in the urine and approximately 60% in the feces. The disposition of the compound in animals is qualitatively similar to that in man. discount bactrim instrukcija
Medication. There are different kinds of medication used to treat BPH. Your doctor has prescribed Hytrin for you. See "What Hytrin does to treat BPH" below. There was a tendency for patients to gain weight during terazosin therapy. In all three studies, both symptom scores and peak urine flow rates showed statistically significant improvement from baseline in patients treated with Hytrin from week 2 or the first clinic visit and throughout the study duration. Similar adverse reaction rates were observed in placebo-controlled monotherapy trials. Includes weakness, tiredness, lassitude and fatigue. If Hytrin is helping you, you should notice an effect on your particular symptoms in 2 to 4 weeks of starting to take the medication. Food and Drug Administration. WebMD does not endorse any specific product, service, or treatment. Do not take other medicines unless they have been discussed with your doctor. This especially includes over-the-counter nonprescription medicines for appetite control, asthma, colds, cough, hay fever, or sinus problems, since they may tend to increase your blood pressure. Analysis of clinical laboratory data following administration of terazosin suggested the possibility of hemodilution based on decreases in hematocrit, hemoglobin, white blood cells, total protein and albumin. Decreases in hematocrit and total protein have been observed with alpha-blockade and are attributed to hemodilution. Hematologic side effects have included thrombocytopenia. Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Cohen J "Long-term efficacy and safety of terazosin. aleve
The greater blood pressure effect associated with peak plasma concentrations first few hours after dosing appears somewhat more position-dependent greater in the erect position than the effect of terazosin at 24 hours and in the erect position there is also a 6-10 beat per minute increase in heart rate in the first few hours after dosing. Hytrin may cause a sudden drop in blood pressure after the first dose. Take your first dose at bedtime. If you get up during the night, sit up slowly, then stand slowly. Both differences were statistically significant. Oddly enough, though, I think this has led to another problem. In a study of 226 patients on terazosin the active ingredient contained in Hytrin for up to 2 years, only 2 discontinued therapy due to rash.
PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Hytrin while you are pregnant. It is not known if this medicine is found in breast milk. If you are or will be breast-feeding while you use Hytrin, check with your doctor. Discuss any possible risks to your baby. Dermatologic side effects of skin rash have been reported rarely. Lichenoid drug eruption has been associated with terazosin the active ingredient contained in Hytrin therapy. If your symptoms do not improve or if they become worse, check with your doctor. Additionally, TRUVEN HEALTH MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Truven Health does not assume any responsibility or risk for your use of the Truven Health products. Hytrin is used to treat high blood pressure hypertension. Hytrin is also used to treat benign prostatic hyperplasia BPH in men. This leaflet describes Hytrin as a treatment for hypertension or BPH. What Is Hypertension High Blood Pressure? Musculoskeletal complaints of pain or cold extremities have been reported in up to 17% and 12% of patients, respectively. Only 4% of 354 patients from a multicenter trial complained of general abdominal pain or diarrhea within the first 90 days of therapy. During cataract surgery, a variant of small pupil syndrome known as Intraoperative Floppy Iris Syndrome IFIS has been reported in association with alpha-1 blocker therapy see PRECAUTIONS. VERY weak urine stream. I find that, as long as I take it on schedule, and don't forget doses, my urine stream has improved a great deal, almost to the level of what I considered normal. tesco pharmacy biaxin prices
The prevalence of adverse reactions has been ascertained from clinical trials conducted primarily in the United States. All adverse experiences events reported during these trials were recorded as adverse reactions. The prevalence rates presented below are based on combined data from fourteen placebo-controlled trials involving once-a-day administration of terazosin, as monotherapy or in combination with other antihypertensive agents, at doses ranging from 1 to 40 mg. Table 3 summarizes those adverse experiences reported for patients in these trials where the prevalence rate in the terazosin group was at least 5%, where the prevalence rate for the terazosin group was at least 2% and was greater than the prevalence rate for the placebo group, or where the reaction is of particular interest. The information contained in the Truven Health Micromedex products as delivered by Drugs. The dose of Hytrin and the dose interval 12 or 24 hours should be adjusted according to the patient's individual blood pressure response. Some MEDICINES MAY INTERACT with Hytrin. If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. The symptoms associated with BPH are related to bladder outlet obstruction, which is comprised of two underlying components: a static component and a dynamic component. The static component is a consequence of an increase in prostate size. Over time, the prostate will continue to enlarge. However, clinical studies have demonstrated that the size of the prostate does not correlate with the severity of BPH symptoms or the degree of urinary obstruction. 1 The dynamic component is a function of an increase in smooth muscle tone in the prostate and bladder neck, leading to constriction of the bladder outlet. Smooth muscle tone is mediated by sympathetic nervous stimulation of alpha-l adrenoceptors, which are abundant in the prostate, prostatic capsule and bladder neck. The reduction in symptoms and improvement in urine flow rates following administration of terazosin is related to relaxation of smooth muscle produced by blockade of alpha-l adrenoceptors in the bladder neck and prostate. Because there are relatively few alpha-l adrenoceptors in the bladder body, terazosin is able to reduce the bladder outlet obstruction without affecting bladder contractility. decadron
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You should see an effect on your symptoms in 2 to 4 weeks. So, you will need to continue seeing your doctor to check your progress regarding your BPH and to monitor your blood pressure in addition to your other regular check-ups. Lepor H "Long-term efficacy and safety of terazosin in patients with benign prostatic hyperplasia. Tell your doctor if you develop any new symptoms.
Follow your doctor's instructions about how to take Hytrin. You must take it every day at the dose prescribed. Talk with your doctor if you don't take it for a few days, you may have to restart it at a 1 mg dose and be cautious about possible dizziness. Do not share Hytrin with anyone else; it was prescribed only for you. Deger G "Comparison of the safety and efficacy of once-daily terazosin versus twice-daily prazosin for the treatment of mild to moderate hypertension. Symptoms may include dizziness; weakness. In addition to the use of the medicine your doctor has prescribed, treatment for your high blood pressure may include weight control and care in the types of foods you eat, especially foods high in sodium. Your doctor will tell you which of these are most important for you. You should check with your doctor before changing your diet.
The absence of mutagenicity in a battery of tests, of tumorigenicity of any cell type in the mouse carcinogenicity assay, of increased total tumor incidence in either species, and of proliferative adrenal lesions in female rats, suggests a male rat species-specific event. Numerous other diverse pharmaceutical and chemical compounds have also been associated with benign adrenal medullary tumors in male rats without supporting evidence for carcinogenicity in man. Hytrin relaxes the tightness of a certain type of muscle in the prostate and at the opening of the bladder. Dizziness, lightheadedness, or sudden fainting may occur after you take this medicine, especially when you get up from a lying or sitting position. These effects are more likely to occur when you take the first dose of this medicine. Taking the first dose at bedtime may prevent problems. However, be especially careful if you need to get up during the night. These effects may also occur with any doses you take after the first dose. Getting up slowly may help lessen this problem. If you feel dizzy, lie down so that you do not faint. Then sit for a few moments before standing to prevent the dizziness from returning.
Yellow No. 6, lactose, magnesium stearate, povidone and talc. It is important that your doctor check your progress at regular visits to make sure that this medicine is working properly. Do not drink alcohol or use medicines that may cause drowsiness eg, sleep aids, muscle relaxers while you are using Hytrin; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.